Know More About This Test

The Quadruple Test is a prenatal blood screening test performed during the second trimester of pregnancy to assess the risk of certain fetal chromosomal abnormalities and neural tube defects. It measures four biochemical markers in the mother's blood: AFP, hCG, estriol, and inhibin A.

This test does not diagnose conditions but estimates the probability of abnormalities.

Why Is This Test Recommended?

It is recommended for pregnant women between 15 and 20 weeks of gestation, especially those with advanced maternal age, family history of genetic disorders, or abnormal first-trimester screening results.

What Do the Results Indicate?

Abnormal levels may indicate increased risk for Down syndrome, Edwards syndrome, or neural tube defects. Normal results suggest low probability but do not completely rule out abnormalities.

How Is the Test Performed and Prepared For?

A blood sample is collected. No fasting is required. Accurate gestational age is crucial for correct interpretation.

Frequently Asked Questions (FAQs)

Is this a diagnostic test?
No, the Quadruple Test is a screening test, not a diagnostic test; it assesses risk probability and abnormal results require follow-up with diagnostic procedures like amniocentesis or detailed ultrasound for confirmation.

Does it harm the baby?
No, the test does not harm the baby as it only involves drawing blood from the mother; it is completely safe and non-invasive for both mother and fetus.

Can abnormal results be false?
Yes, abnormal results can be false positives, meaning the test indicates elevated risk even when the baby is healthy; factors like incorrect gestational age calculation or multiple pregnancy can affect accuracy.

What follows an abnormal result?
Further testing is recommended following an abnormal result, which may include detailed ultrasound examination, amniocentesis, or genetic counseling to confirm or rule out suspected abnormalities.

Is ultrasound also required?
Usually yes, ultrasound is typically required alongside the Quadruple Test to confirm gestational age, assess fetal anatomy, detect structural abnormalities, and provide comprehensive prenatal screening.